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Pregnancy complications more likely in women with sleep apnea: http://www.cleveland.com/medical/plaindealer/index.ssf?/base/news/1...

Two studies presented last week at the annual meeting of the Associated Professional Sleep Societies underscore the need for pregnant women to get a sound night's sleep.

Researchers at MetroHealth Medical Center reviewed the medical records of women who delivered at MetroHealth between 2000 and 2008 who had been diagnosed with obstructive sleep apnea prior to or during their pregnancy. They found that having sleep apnea -- stopping breathing temporarily while asleep -- during pregnancy is associated with a higher risk of delivering a preterm baby or a baby of higher than normal birth weight.

"There's really very limited information on these women," said lead researcher Dr. Judette Louis, an obstetrician-gynecologist.

Because of previous studies, researchers had anticipated seeing babies born prematurely, Louis said. They were surprised by the babies who were large for their gestational age.

Because obesity is one of the main causes of sleep apnea, women with the condition should try to lose weight before becoming pregnant, Louis said.

The study highlights the need to find a better way to screen women for sleep apnea, Louis said. An estimated 18 million Americans have sleep apnea, but about 90 percent of them don't know it, she said.

Another study, this one from researchers at Northwestern University's Feinberg School of Medicine, is the first to report a link between snoring and gestational diabetes. The study also found that pregnancy increases the likelihood that a woman will snore. Snoring during pregnancy may be triggered by weight gain and a buildup of fluid that can increase airway resistance.

For the study, 189 healthy women completed a sleep survey at the time of enrollment (six to 20 weeks gestation) and in the third trimester.

Pregnant women who were frequent snorers had a higher risk of developing gestational diabetes than nonsnoring women.

"Snoring may be a sign of poor airflow and diminished oxygenation during sleep that can cause a cascade of events in your body," said Dr. Francesca Facco, the study's principal investigator and a fellow at the medical school.

"This may activate your sympathetic nervous system, so your blood pressure rises at night," she said. "This can also provoke inflammatory and metabolic changes, increasing the risk of diabetes or poor sugar tolerance."

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Actually, this is not new information. There have been studies in the past that showed a higher incidence of glucose intolerance, high blood pressure, lower Apgar scores and lower birth weights in women who snore or have obstructive sleep apnea. One important condition that was not mentioned is the increased incidence of pre-eclampsia, a dangerous complication of pregnancy for both the mother and the baby. Using CPAP was found beneficial in treating this condition.
on a personal note, my wife has mild sleep apnea, is being treated with CPAP, and is pregnant. a blood test came back with higher than normal levels of inhibin and HcG that have been associated with greater risk of pre-eclampsia. so i'm glad that you mentioned that treating sleep apnea well might mitigate the pre-eclampsia risk. the doctors told us there was nothing that could be done about it, and so they even wonder whether to tell patients about it since there's nothing they can do.

Steven Y. Park, MD said:
Actually, this is not new information. There have been studies in the past that showed a higher incidence of glucose intolerance, high blood pressure, lower Apgar scores and lower birth weights in women who snore or have obstructive sleep apnea. One important condition that was not mentioned is the increased incidence of pre-eclampsia, a dangerous complication of pregnancy for both the mother and the baby. Using CPAP was found beneficial in treating this condition.

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