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I believe the recommendation for NeilMed nasal rinse is to limit use to only twice a day. My wife is using it sometimes 3 times a day, without any side-effects. Anyone know of a reason to be wary here other than the manufacturer's warning?

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I know that the reason we have mucus membranes is to help with our bodies natural defense against germs.

Is it possible that washing out the mucus might have a negative impact on our immunity?
Interesting question...found two things on this on the web:

For general nasal cleanliness, once or twice a day is usually sufficient. Nasal Cleansing is best practiced first thing in the morning to clear out the night's grogginess and prepare the body for the day's breathing activities. However, if you live or work in a dusty or polluted environment where the nostrils have an increased load of filtering, a good second occasion is upon returning from such work. Neti should always be done before rather than after meals. It can be done up to a maximum of 4 times a day for therapeutic applications: upon waking before breakfast, before lunch, before dinner, before bed; but only upon qualified advice. In the case of a cold, 3 - 4 times a day will give great relief, providing the nose is well dried and this frequency does not induce nose bleeds.

www.soul-guidance.com

Recommended Frequency of Neti Practice For general nasal cleanliness, once or twice a day is usually sufficient.
In the case of a cold, 3 - 4 times a day will give great relief, providing the nose is well dried each time and this frequency does not induce nose bleeds. Reduce this frequency when over the worst of the congestion.


http://www.jalanetipot.com/how_stage3.html

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