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Genetic Mutation Tied to Needing Less Sleep: http://www.nytimes.com/2009/08/14/health/research/14sleep.html?_r=1

This is pretty huge, as evidenced by Dr. Charles A. Czeisler's enthusiasm. He's a very prominent guy in the sleep medicine field. If he's excited, that says something.

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That's very interesting!

Thank you for sharing it. I think Starbucks is going to put a hit out on Dr. Czeisler...

Jason
I have just read about the same study in a Danish newspaper.

It cannot be read directly in the article, but it is demonstrated that the sleep stage 2 is missing in these people. (In reality a unnecessary part of Sleep)

Henning
I do think that this is a huge find. However it is far to early in the evolution of the sleep field to rule out any stage of sleep as "un-needed".

Résumé / Abstract
It has become increasingly clear that sleep is necessary for efficient memory consolidation. Recently, it has been found that Stage 2 sleep disruption impairs procedural memory performance, and that memory performance is correlated with the duration of Stage 2 sleep; but the mechanisms involved in synaptic plasticity for procedural memory during sleep have not been identified. The present study examined the learning-dependent changes in sleep, including Stage 2 sleep spindles. Following an intense period of simple motor procedural learning, the duration of Stage 2 sleep and spindle density increased. There were no changes observed in the duration of any other stage of sleep or in the density of rapid eye movements. These findings support the . hypothesis that sleep spindles are involved in the off-line reprocessing of simple motor procedural memory during Stage 2 sleep

http://www.google.com/search?q=stage+2+sleep+and+memory&sourcei...

Various studies have demonstrated that a night of sleep has a beneficial effect on the retention of previously acquired declarative material. In two experiments, we addressed the question of whether this effect extends to daytime naps. In the first experiment we assessed free recall of a list of 30 words after a 60 min retention interval that was either filled with daytime napping or waking activity. Memory performance was significantly enhanced after napping as opposed to waking but was not correlated with time spent in slow wave sleep or total sleep time within the napping condition. The second experiment was designed to clarify the role of total sleep time and therefore included an additional third group, which was allowed to nap for no longer than 6 min on average. In comparing word recall after conditions of no napping (waking), short napping, and long napping, we found superior recall for both nap conditions in contrast to waking as well as for long naps in contrast to short naps. These results demonstrate that even an ultra short period of sleep is sufficient to enhance memory processing. We suggest that the mere onset of sleep may initiate active processes of consolidation which – once triggered – remain effective even if sleep is terminated shortly thereafter
It does seem unlikely to me that this machine called the human body that is otherwise so efficient would have us go through a stage of sleep every night that is unnecessary.

Rock Hinkle said:
I do think that this is a huge find. However it is far to early in the evolution of the sleep field to rule out any stage of sleep as "un-needed".

Résumé / Abstract
It has become increasingly clear that sleep is necessary for efficient memory consolidation. Recently, it has been found that Stage 2 sleep disruption impairs procedural memory performance, and that memory performance is correlated with the duration of Stage 2 sleep; but the mechanisms involved in synaptic plasticity for procedural memory during sleep have not been identified. The present study examined the learning-dependent changes in sleep, including Stage 2 sleep spindles. Following an intense period of simple motor procedural learning, the duration of Stage 2 sleep and spindle density increased. There were no changes observed in the duration of any other stage of sleep or in the density of rapid eye movements. These findings support the . hypothesis that sleep spindles are involved in the off-line reprocessing of simple motor procedural memory during Stage 2 sleep

http://www.google.com/search?q=stage+2+sleep+and+memory&sourcei...

Various studies have demonstrated that a night of sleep has a beneficial effect on the retention of previously acquired declarative material. In two experiments, we addressed the question of whether this effect extends to daytime naps. In the first experiment we assessed free recall of a list of 30 words after a 60 min retention interval that was either filled with daytime napping or waking activity. Memory performance was significantly enhanced after napping as opposed to waking but was not correlated with time spent in slow wave sleep or total sleep time within the napping condition. The second experiment was designed to clarify the role of total sleep time and therefore included an additional third group, which was allowed to nap for no longer than 6 min on average. In comparing word recall after conditions of no napping (waking), short napping, and long napping, we found superior recall for both nap conditions in contrast to waking as well as for long naps in contrast to short naps. These results demonstrate that even an ultra short period of sleep is sufficient to enhance memory processing. We suggest that the mere onset of sleep may initiate active processes of consolidation which – once triggered – remain effective even if sleep is terminated shortly thereafter
I cannot answer it.

But my wife is one of the 5% who only need 5-6 hours of sleep each night. She starts with the deep sleep in 2 to 3 hours, after which she has REM sleep the rest of the night.

She has never needed a nap and she is very energetic.

So she matches the study very well. I envy her this, think of all the hours we are wasting.

Henning
What kind of sleep does she have between sleep onset and Deep sleep?

Henning said:
I cannot answer it.

But my wife is one of the 5% who only need 5-6 hours of sleep each night. She starts with the deep sleep in 2 to 3 hours, after which she has REM sleep the rest of the night.

She has never needed a nap and she is very energetic.

So she matches the study very well. I envy her this, think of all the hours we are wasting.

Henning
Now, she has never had a sleep study, but within minutes she is in very deep sleep. (I don't think she will wake up if a bomb jumps).

After 2 to 3 hours of sleep she will wake at the slightest sound and she have a lot of dreams.

What impresses me is her energy level with this short sleep.

Henning
It would be interesting to see what her sleep looks like.
I agree with you in that.

All in her family sleep in the same way, and they all get very old, and have a high energy level.

So I am sure there is much we still do not know about sleep.

Henning
As the average person grows we see a merge of stage 4- stage 3 into stage 2 sleep. A person over the age of 60 might not have any conclusive stage 3. I wonder if peple with this gene have it the opposite. Stage 2 and 4 merging into stage 3. HMMMM!

I do believe that one of the keys to retaining youth and health is by retaining as much stage 3 sleep for as long as possible.
I really think it could be an explanation.

I am 57 years and looks like a person at 57 years.

My wife is 65 and looks like she is at least 10 years younger than me. So perhaps there is a link between this gene modification and aging.

It will be very interesting to pursue further studies on this topic.

Henning


Rock Hinkle said:
As the average person grows we see a merge of stage 4- stage 3 into stage 2 sleep. A person over the age of 60 might not have any conclusive stage 3. I wonder if peple with this gene have it the opposite. Stage 2 and 4 merging into stage 3. HMMMM!
I do believe that one of the keys to retaining youth and health is by retaining as much stage 3 sleep for as long as possible.
I have found that older people that look younger tend to retain more stage 3 sleep. These same people (at least the ones I have asked) tend to get some sort of daily exercise. These are just my own observations though.

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