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Bananas, Didgeridoos and now Surface Lubricants and OSA
Am. J. Respir. Crit. Care Med., Volume 157, Number 5, May 1998, 1522-1525
Surface Tension Forces in Sleep Apnea: The Role of a Soft Tissue Lubricant
A Randomized Double-blind, Placebo-controlled Trial
RUZICA JOKIC, ARTUR KLIMASZEWSKI, JOSEPH MINK, and MICHAEL F. FITZPATRICK
Division of Respiratory Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Upper airway obstruction in patients with sleep apnea may occur in the absence of a negative intraluminal upper airway pressure. We hypothesized that surface tension forces may play a role in the pathogenesis of obstructive sleep apnea (OSA), and that a topical soft tissue lubricant might reduce the severity of OSA. Ten male patients (age 49 ± 10 yr [mean ± SD]; body mass index [BMI] 31 ± 5 kg/m2) with OSA (apnea-hypopnea index [AHI] 17 ± 9) were studied. The arousal index was lower with the lubricant treatment than with placebo (mean difference 8; 95% CI 4 to 11 arousals/h; p = 0.001). The AHI was lower, in each of the 10 patients, on the lubricant treatment than the placebo (mean change 10, 95% CI 6 to 13; p = 0.0003). The lower AHI with lubricant as compared with placebo was present in both supine (mean difference 13; 95% CI 5 to 20; p = 0.006) and nonsupine (mean difference 6; 95% CI 0 to 12; p = 0.05) positions. There was no significant difference in sleep architecture between the lubricant and placebo treatments. Application of a topical lubricant consistently reduced the severity of OSA. This implies a pathogenetic role for surface tension forces in OSA, and a potential role for surface tension-reducing agents in the treatment of OSA.
Surface Tension Forces in Sleep Apnea: The Role of a Soft Tissue Lubricant
A Randomized Double-blind, Placebo-controlled Trial
RUZICA JOKIC, ARTUR KLIMASZEWSKI, JOSEPH MINK, and MICHAEL F. FITZPATRICK
Division of Respiratory Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Upper airway obstruction in patients with sleep apnea may occur in the absence of a negative intraluminal upper airway pressure. We hypothesized that surface tension forces may play a role in the pathogenesis of obstructive sleep apnea (OSA), and that a topical soft tissue lubricant might reduce the severity of OSA. Ten male patients (age 49 ± 10 yr [mean ± SD]; body mass index [BMI] 31 ± 5 kg/m2) with OSA (apnea-hypopnea index [AHI] 17 ± 9) were studied. The arousal index was lower with the lubricant treatment than with placebo (mean difference 8; 95% CI 4 to 11 arousals/h; p = 0.001). The AHI was lower, in each of the 10 patients, on the lubricant treatment than the placebo (mean change 10, 95% CI 6 to 13; p = 0.0003). The lower AHI with lubricant as compared with placebo was present in both supine (mean difference 13; 95% CI 5 to 20; p = 0.006) and nonsupine (mean difference 6; 95% CI 0 to 12; p = 0.05) positions. There was no significant difference in sleep architecture between the lubricant and placebo treatments. Application of a topical lubricant consistently reduced the severity of OSA. This implies a pathogenetic role for surface tension forces in OSA, and a potential role for surface tension-reducing agents in the treatment of OSA.
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Replies to This Discussion
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Permalink Reply by 99 on
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what is the lubricant used
The Role of a Soft Tissue Lubricant
A Randomized Double-blind, Placebo-controlled Trial
RUZICA JOKIC, ARTUR KLIMASZEWSKI, JOSEPH MINK, and MICHAEL F. FITZPATRICK
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Application of a topical lubricant consistently reduced the severity of OSA. This implies a pathogenetic role for surface tension forces in OSA, and a potential role for surface tension-reducing agents in the treatment of OSA.
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Permalink Reply by MZH on
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Mike C, my speech therapist who deals with very sick people every day, suggested I try Expand-a-lung. I think you should check it out. Just Google it and it'll come right up. I tried one at therapy today and I can see how it would help.
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The blood clots in your lungs may well be an issue. Oy.
Mike C (STILL at the Beach!) said:Thank you for that! This is something I actually know NOTHING about....I Googled it and am trying to determine if it would serve me, OR cause me risk due to multiple bilateral blood clots in my lungs. Normally I would just ask my doctor or Pulmonologist. But I quit seeing doctors so will look into this & study. Really does seem to be a simple tool that should help.
MZH said:Mike C, my speech therapist who deals with very sick people every day, suggested I try Expand-a-lung. I think you should check it out. Just Google it and it'll come right up. I tried one at therapy today and I can see how it would help.
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